名称: Recombinant Human Tumor necrosis factor receptor superfamily member 17(TNFRSF17)
产品货号:AA10340
规格:20ug 100ug 1mg
产品详情
纯度:Greater than 90% as determined by SDS-PAGE.
内毒素:Less than 1.0 EU/ug as determined by LAL method.
生物活性:①Measured by its binding ability in a functional ELISA. Immobilized BCMA at 2μg/ml can bind Anti-BCMA recombinant antibody, the EC50 of human BCMA protein is 1.912-2.488 ng/ml.②Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 10μg/ml can bind human BCMA, the EC50 of human BCMA protein is 221.3-298.6 ng/ml.③Human TNFSF13B protein Fc tag captured on COOH chip can bind Human BCMA protein Fc tag with an affinity constant of 39 nM as detected by LSPR Assay.④Measured by its binding ability in a functional ELISA. Immobilized human BCMA at 5μg/ml can bind Biotinylated human TNFSF13B, the EC50 is 0.1752-0.3657 ng/ml.
基因名:TNFRSF17
Uniprot No.:Q02223
别名:B cell maturation antigen; B cell maturation factor; B cell maturation protein; B-cell maturation protein; BCM; BCMA; CD269; CD269 antigen; TNFRSF17; TNR17_HUMAN; Tumor necrosis factor receptor superfamily member 17
种属:Homo sapiens (Human)
蛋白长度:Partial
来源:Mammalian cell
分子量:34.8 kDa
表达区域:1-54aa
蛋白标签:C-terminal hFc-tagged
产品提供形式:Liquid or Lyophilized powder
产品描述:重组人受体超家族成员17 (TNFRSF17)是一种在哺乳动物细胞中产生的部分长度受体。编码TNFRSF17 (1-54aa)的DNA序列与c端fc标签融合。重组TNFRSF17在涉及癌细胞的研究中得到应用。
TNFRSF17是一种通常在b细胞上表达的细胞表面受体。它由来自TNF 13b超家族和TRAF家族的配体激活。在激活时,它传递参与NF-kb和JNK/MAPK8通路激活的信号。
在t细胞急性淋巴细胞中,TNFRSF17的染色体错误与NF-kb和JNK的异常激活有关。NF-kb和JNK通路的异常激活有助于癌细胞的增殖、转移、生成和的凋亡。
经不连续SDS-PAGE验证,产品分子量为34.8 kDa,纯度超过90%。用ELISA和LSPR法验证了其活性。
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